Heparin Contamination & Possible Screening Test

ClotCare: Blood Clots, Stroke, Heart Attack

Tuesday, December 3, 2024

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Pick a Topic: Home New Postings Patient Postings Clinician Postings Join Our Email List Useful Web Links CE Opportunities Training Programs Guidelines DVT & PE Stories Editorial Board Financial Support About ClotCare DVT Coalition Contact Us Find info on a: Specific Medicine or Treatment Type of Medicine or Treatment Condition or Medical Procedure Lab Test Procedure Management Issue ClotCare complies with the HONcode standard for trustworthy health information: verify here. ClotCare is a member organization of the Coalition to Prevent Deep Vein Thrombosis. Click here to learn more about the Coalition to Prevent Deep Vein Thrombosis and DVT Awareness Month, which is held each March.	Heparin Contamination More information on the recent heparin contamination problem reported from the Center for Disease Control (CDC) Henry I. Bussey, Pharm.D., FCCP, FAHA December, 2008 According to theheart.org (theheart.org/viewArticle.do?primaryKey=926377&nl_id=tho03dec08), the December 3, 2008 issue of the New England Journal of Medicine contains two articles of interest on this issue. The first (1) is a report from the CDC that summarizes what has been learned by a collaborative effort to review and document potential cases of adverse effects due to contaminated heparins that were recently pulled from the market. This report also indicates that U.S. manufacturers have agreed to employ certain tests to evaluate heparins that may be contaminated with over sulfated chondroitin sulfate (the contaminant thought to be responsible for the reported adverse effects, some of which were fatal). The second article (2) suggests that, at certain threshold concentrations, over sulfated chondroitin sulfate will increase the prothrombin which, therefore, may be useful as a quick clinical test to determine if such contamination may be present when suspected. References Blossom DB, Kallen AJ, Patel PR, et al. Outbreak of adverse reactions associated with contaminated heparin. N Engl J Med 2008; 359:2674-2684. Alban S, Lühn S. Prothrombin time for detection of contaminated heparins. N Engl J Med 2008; 359:2732-2733.	Have questions? Ask ClotCare. Send questions by email to webmaster@clotcare.org. ClotCare is a 501(c)(3) non-profit organization generously supported by your tax-deductible donations and grants from our industry supporters. New Postings: Click here to view full list of new postings
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Key topics discussed on ClotCare include: Blood Clots \| Deep Vein Thrombosis (DVT) \| Pulmonary Embolism (PE) \| Atrial Fibrillation (A. Fib or AF) \| Heart Attack \| Stroke \| Transient Ischemic Attack (TIA) \| Mini Stroke \| Bleeding Complications \| Vascular Surgery \| Surgical Blood Clot Removal \| Warfarin \| Coumadin \| Lovenox \| Low Molecular Weight Heparin (LMWH) \| Heparin \| Anticoagulants \| Plavix \| Aspirin \| Antiplatelets \| Blood Thinners
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