ClotCare: Blood Clots, Stroke, Heart Attack
Wednesday, October 30, 2024
Home   |   DVT/PE   |   Blood Clots   |   Coumadin/Warfarin   |   New Patients   |   Self Testing   |   Email List   |   Donate

Pick a Topic:

Find info on a:

We subscribe to the HONcode principles of the HON Foundation. Click to verify.
ClotCare complies with the HONcode standard for trustworthy health
information:
verify here.

ClotCare is a member of the Coalition to Prevent Deep Vein Thrombosis (DVT Coalition)  ClotCare is a member organization of the Coalition to Prevent Deep Vein Thrombosis. Click here to learn more about the Coalition to Prevent Deep Vein Thrombosis and DVT Awareness Month, which is held each March.

Dronedarone (Multaq) permanent atrial fibrillation study (“PALLAS”) stopped early due to increased major cardiovascular events in active treatment group

Henry I. Bussey, Pharm.D., FCCP, FAHA
July, 2011

The heart.org just released a write-up on a press release from Sanofi-Aventis which announced the decision to terminate the phase IIIb “PALLAS” study (see http://www.theheart.org/article/1251405.do?utm_campaign
=newsletter&utm_medium=email&utm_source=20110707_breaking
).

Dr. Stuart Connolly, a co-primary investigator, was not able to provide details about specific event rates that led to the termination of PALLAS, but he pointed out that the patients in the PALLAS study were very different from the patients in the ATHENA study (which previously reported benefits with dronedarone therapy). Specifically, patients in the ATHENA study had intermittent atrial fibrillation and relatively mild additional risk factors. By contrast, the patients in PALLAS had permanent atrial fibrillation and more severe risk factors (including previous stroke or myocardial infarction, reduced ejection fraction, and others). Previously, concerns had arisen about the safety of dronedarone in certain patients, particularly those with heart failure. Dr. Connolly did not feel that dronedarone needed to be stopped in “ATHENA – like” patients who have been taking this medication for its approved indication of intermittent atrial fibrillation.

Ask a question about blood clots or anticoagulant medications Have questions? Ask ClotCare. Send questions by email to webmaster@clotcare.org.

ClotCare is a 501(c)(3) non-profit organization generously supported by your tax-deductible donations and grants from our industry supporters.

Blood Clot Activities Calendar

New Postings:

Click here to view full list of new postings
ClotCare Home | New Postings | Patient Postings | Clinician Postings | Join Our Email List | Useful Web Links
CE Opportunities | Training Programs | DVT & PE Stories | Editorial Board | Financial Support
About ClotCare | DVT Coalition | Donate to ClotCare | Contact Us
Key topics discussed on ClotCare include: Blood Clots | Deep Vein Thrombosis (DVT) | Pulmonary Embolism (PE) | Atrial Fibrillation (A. Fib or AF) | Heart Attack | Stroke | Transient Ischemic Attack (TIA) | Mini Stroke | Bleeding Complications | Vascular Surgery | Surgical Blood Clot Removal | Warfarin | Coumadin | Lovenox | Low Molecular Weight Heparin (LMWH) | Heparin | Anticoagulants | Plavix | Aspirin | Antiplatelets | Blood Thinners
Copyright 2000-2018 by ClotCare. All rights reserved.
Terms, Conditions, & Privacy | Image Copyright Information
19260 Stone Oak Parkway, Suite 101 | San Antonio, TX 78258 | 210-860-0487
Send comments to webmaster@clotcare.org.
Wednesday, October 30, 2024