ClotCare: Blood Clots, Stroke, Heart Attack
Wednesday, May 22, 2024
Home   |   DVT/PE   |   Blood Clots   |   Coumadin/Warfarin   |   New Patients   |   Self Testing   |   Email List   |   Donate

Pick a Topic:

Find info on a:

We subscribe to the HONcode principles of the HON Foundation. Click to verify.
ClotCare complies with the HONcode standard for trustworthy health
verify here.

ClotCare is a member of the Coalition to Prevent Deep Vein Thrombosis (DVT Coalition)  ClotCare is a member organization of the Coalition to Prevent Deep Vein Thrombosis. Click here to learn more about the Coalition to Prevent Deep Vein Thrombosis and DVT Awareness Month, which is held each March.

D-Dimer Testing to Exclude Recurrent DVT

Henry I. Bussey, Pharm.D., FCCP, FAHA
January, 2005

Review: Rathbun SW, Whitsett TL, Raskob GE. Negative d-Dimer result to exclude recurrent deep venous thrombosis: A management trial. Ann Intern Med. 2004; 839-845.

Although several studies have discussed using d-Dimer testing to rule out acute DVT or PE, we are unaware of similar data regarding patients with recurrent DVT. Because of the occurrence of post-thrombotic syndrome in patients with a prior DVT, it is often especially difficult to determine whether worsening symptoms are due to changes in the post-thrombotic syndrome or may represent a new thromboembolic event.

In the present study, investigators measured d-Dimer levels in 300 consecutive patients suspected of having a recurrent DVT. Those with a negative d-Dimer were not treated with anticoagulation and no further testing was done during the acute phase. Patients with a negative test were followed up in 3 months or less if new symptoms developed. Of 166 patients (55%) with a positive d-Dimer test, ultrasound results confirmed a new DVT in 54, was normal in 79, and inconclusive in 33. Of 134 patients (45%) with a negative d-Dimer, 1 had a confirmed venous thromboembolic event or VTE (0.75%). VTE could not be excluded in 6 with leg symptoms (5 had inconclusive tests, and 1 was not tested) and one patient who died. Even if these 7 patients were included as having a VTE, the incidence would be only 6%

Ask a question about blood clots or anticoagulant medications Have questions? Ask ClotCare. Send questions by email to

ClotCare is a 501(c)(3) non-profit organization generously supported by your tax-deductible donations and grants from our industry supporters.

Blood Clot Activities Calendar

New Postings:

Click here to view full list of new postings
ClotCare Home | New Postings | Patient Postings | Clinician Postings | Join Our Email List | Useful Web Links
CE Opportunities | Training Programs | DVT & PE Stories | Editorial Board | Financial Support
About ClotCare | DVT Coalition | Donate to ClotCare | Contact Us
Key topics discussed on ClotCare include: Blood Clots | Deep Vein Thrombosis (DVT) | Pulmonary Embolism (PE) | Atrial Fibrillation (A. Fib or AF) | Heart Attack | Stroke | Transient Ischemic Attack (TIA) | Mini Stroke | Bleeding Complications | Vascular Surgery | Surgical Blood Clot Removal | Warfarin | Coumadin | Lovenox | Low Molecular Weight Heparin (LMWH) | Heparin | Anticoagulants | Plavix | Aspirin | Antiplatelets | Blood Thinners
Copyright 2000-2018 by ClotCare. All rights reserved.
Terms, Conditions, & Privacy | Image Copyright Information
19260 Stone Oak Parkway, Suite 101 | San Antonio, TX 78258 | 210-860-0487
Send comments to
Wednesday, May 22, 2024